Redwood DG, Dinh TA, Kisiel JB, et al. - This study was undertaken to investigate the cost-effectiveness of multitarget stool DNA testing (MT-sDNA) compared with colonoscopy and fecal immunochemical testing (FIT) for Alaska Native adults. Researchers used a Markov model to calculate the three screening test effects over 40 years. Compared with no screening, each strategy reduced costs and increased quality-adjusted life-years (QALYs). It has been reported that screening by MT-sDNA results in the largest QALY savings. The results revealed that screening by MT-sDNA in the Alaska Native population was cost-effective compared with screening by colonoscopy and FIT for a wide range of adherence scenarios in Markov model analysis. With perfect adherence, CRC incidence was reduced by 52% with colonoscopy, 61% with annual FIT, and 66% with MT-sDNA.