Abraham P, et al. - In the treatment of high-grade glioma, researchers sought to build a clinical decision analysis model for evaluating intraoperative MRI. To follow patients with high-grade glioma, an integrated five-state microsimulation model was built. For this analysis, 100,000 treated with intraoperative MRI were compared with 100,000 patients treated from initial resection and debulking to death without intraoperative MRI. According to findings, intraoperative MRI in the treatment of high-grade glioma is likely to be a cost-effective method, as seen with probabilistic sensitivity analysis which showed, at a willingness-to-pay threshold of $100 000 per QALY, intraoperative MRI had a 99.5% chance of being cost-effective.