Roberts–Thomson IC, et al. – In this study, authors focused on cost–effective options for the prevention and management of gastrointestinal and liver disease in the Asia–Pacific region. As per observations, in these regions approximately 50% of infant deaths [<5years] are caused by gastroenteritis, the major pathogen being rotavirus infection. Rotavirus vaccines appeared cost–effective but, thus far, have not been widely adopted. In contrast, the adoption of infant vaccination for hepatitis B in most countries had led to a striking reduction in the prevalence of infection in vaccinated individuals. Cost–effectiveness analyses, applied to newer and more expensive drugs for hepatitis B and C and to government–sponsored programs for the early detection of hepatocellular, gastric and colorectal cancer, revealed that newer drugs and surveillance programs for cancer were only marginally cost–effective in the setting of a high–income country.