Leeds IL, DiBrito SR, Canner JK, et al. - The cost-efficacy of extended prophylaxis in patients with Crohn disease after abdominal surgery was assessed employing a decision tree model to estimate the incremental cost-effectiveness and cost per case averted with extended-duration venous thromboembolism prophylaxis following abdominal surgery. Researchers used existing published sources to ascertain the risk of a postdischarge thrombotic event, age at surgery, type of thrombotic event, prophylaxis risk reduction, bleeding complications, and mortality. With the use of reference parameters, the individual without prophylaxis is expected to confer a total cost of care of $399.83 to the society vs $1387.95 for those with prophylaxis. Findings suggest that in patients with Crohn disease postoperative extended prophylaxis is not cost-effective when the cumulative incidence of posthospital thrombosis remains less than 4.9%. The low absolute risk of thrombosis in this population and the considerable cost of universal treatment seemed driving these findings.