Kumar S, Thavorn K, van Katwyk S, et al. - Researchers conducted the study for comparing costs and quality‐adjusted life years of patients receiving endoscopic polypectomy in the clinic those receiving endoscopic sinus surgery from the perspective of Canada's health system. A Markov model was developed to simulate costs and quality‐adjusted life years among a cohort of patients with chronic rhinosinusitis with polyps who received endoscopic polypectomy in clinic or endoscopic sinus surgery, over a patient's lifetime. Clinical endoscopic polypectomy was a cost‐saving option as it had a lower cost (C$736 vs C$6,728) and provided more quality‐adjusted life years (13.85 vs 13.06) relative to endoscopic sinus surgery. Through the publicly funded healthcare system's viewpoint, endoscopic polypectomy in the clinic was economically beneficial relative to endoscopic sinus surgery for chronic rhinosinusitis with polyps patients with primary bilateral nasal obstruction symptoms. However, the cost-effectiveness findings are highly dependent on the relative impact on post-surgery health utility values of endoscopic polypectomy in clinic and endoscopic sinus surgery.