Costa LR, et al. - Researchers conducted the study for prospectively analyzing the correlation between changes in cortical bone density and coronary artery calcification (CAC) progression in non-dialyzed chronic kidney disease (CKD) individuals. Utilizing vertebral tomographic images from a prospective study, changes of cortical and trabecular bone, and changes of calcium score, have been analyzed. For this investigation, 70 asymptomatic individuals [57.8 ± 10.2 years, 63% males, 20% diabetic, estimated glomerular filtration rate = 37.3 (24.8–51.3) mL/min/1.73m²] were followed for 24 months. Over time, the mean cortical and trabecular bone density (BD) did not change. No connection was found between cortical and trabecular BD changes. CKD patients experience cortical or trabecular bone loss over time, but these changes do not occur simultaneously in all patients. Cortical, unlike trabecular bone loss, is not related to the progression of vascular calcification in these patients.