van Wijnen A, Petrov F, Maiworm M, et al. - Multiparametric quantitative MRI (qMRI)-data were obtained from 34 individuals/24 matched healthy controls in order to evaluate cortical damage in individuals with relapsing-remitting multiple sclerosis (RRMS)/clinically isolated syndrome (CIS) with a multiparametric, surface-based qMRI approach and to assess the association of imaging-derived parameters with cognitive scores, assuming that qMRI parameters were related to cognitive abilities. Across the cortex in RRMS/CIS, microstructural variations were randomized diversely. For the evaluation of cognitive impairment in these patients for clinical studies, qMRI was found out to have the potential to give substitute parameters. Moreover, the features of cognitive impairment in RRMS might be dependent on the distribution of cortical variations.