Lien CF, et al. - Given that the high incidence of second esophageal neoplasia is one of the major causes of poor prognosis in hypopharyngeal carcinoma, experts tried to find a biomarker to predict second esophageal neoplasia in this patient population. In patients with hypopharyngeal carcinoma, a potential biomarker for predicting second esophageal neoplasia was identified for the first time in this study. Age, cortactin overexpression, and stage IV versus I independently predicted second esophageal neoplasia. Close surveillance for second esophageal neoplasia is required in those patients with cortactin overexpression and younger age (≤60 years old). Moreover, they noted a requirement of the real effect of cortactin overexpression on the development of primary esophageal carcinoma to be validated in a large cohort study.