Nauta JF, et al. - Researchers carried out a systematic review of five echocardiographic parameters (left atrial volume index, left ventricular mass index, tricuspid regurgitation velocity, myocardial tissue velocity, and the ratio of early mitral inflow to tissue velocity of the mitral annulus [E/e']) at rest to assess the association of these parameters with left ventricular filling pressures in patients with heart failure with preserved ejection fraction (HFpEF), as well as, the prognostic value of these parameters. These parameters are recommended in both the current European Society of Cardiology heart failure guidelines and the American Society of Echocardiography/European Association of Cardiovascular Imaging recommendations for the evaluation of left ventricular diastolic function. Findings showed the use of these parameters at rest in patients with HFpEF was valid in only a small number of studies. E/e' appeared to be the best established parameter, but they found only modest correlations of E/e' with invasive filling pressures and outcomes in HFpEF.