Gupta MK, Yadav G, Singh Y, et al. - For predicting outcome from sepsis and septic shock, more accurate information is retrieved from changing trends of serum lactate and red cell distribution width (RDW). Researchers conducted this prospective observational study with the aim to determine the association, for initial and changing trend of blood lactate level and RDW, with 28-day mortality in sepsis and septic shock. Inclusion was performed of patients fulfilling the criteria of sepsis and septic shock, according to the consensus conference published in 2016. Resuscitation and management according to institutional protocol for sepsis and septic shock were performed in all patients. In the non-survival group, a positive correlation was noted between serum lactate and RDW at the all-time point while the survival group displayed a negative correlation except on day1 and 2. These findings support the possible utility of changing trends of serum lactate and RDW as a prognostic marker in patients of sepsis and septic shock.