Huang WSW, et al. - In this study, the role of CHI3L1 single-nucleotide polymorphisms (SNPs) in hepatocellular carcinoma (HCC) susceptibility and clinicopathology was analyzed. The outcomes demonstrate that patients with CHI3L1 rs880633 variant genotypes TC+CC are at a higher risk of HCC. It was considered that CHI3L1 polymorphisms rs880633 or rs4950928 may be potential candidates for predicting poor HCC prognosis and clinical status.