Yokouchi H, et al. - Authors evaluated 23 right eyes of 23 candidates to study the influence of variations in the serum levels of vascular endothelial growth factor (VEGF) after thalidomide therapy on the peripapillary retinal thickness (pRT) correlated with optic disc oedema (ODE) in subjects with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome. They noted that the mean serum level of VEGF was significantly reduced from 7153±4214 pg/mL to 1067±769 pg/mL 6 months after treatment whereas the pRT was significantly reduced from 471.2±203 µm to 318.1±53.9 µm. A linear and significant correlation of change in the pRT from baseline was noticed with the change in the serum level of VEGF from that at 6 months after treatment.