Das U, Patel R, Guditi S, et al. - This study was undertaken to investigate the relationship of sustained complete clinical remission (CR) in severe lupus nephritis with histological findings on repeat kidney biopsy and appropriate duration of treatment in the maintenance phase after achieving complete clinical remission. Researchers conducted repeated kidney biopsy (biopsy 2) on patients of biopsy-proven (biopsy 1) proliferative lupus nephritis (LN) who had been in CR for at least 2-years. They compared the clinical and histologic findings of these groups (biopsy 1 and biopsy 2). For the final analysis, a total of 29 patients were enrolled. The data demonstrated that sustained CR on maintenance immunosuppressive therapy for more than 48-months duration predicts HR in repeat kidney biopsy findings in quiescent proliferative LN. Hence, in proliferative LN, the minimum duration of maintenance therapy should be at least for another 48 months after achieving CR.