Huayllas MKP, Sirinen GK, Smith LM, et al. - This study was undertaken to investigate the association between adrenal nodule size measured on CT and autonomous cortisol secretion. Researchers assessed maximum nodule diameter on CT and serum cortisol levels at 8:00 am, 60 minutes after the adrenocorticotropic hormone stimulation test, and after the dexamethasone suppression test in a prospective study of 73 individuals 22–87 years old with incidentalomas, unilateral in 52 individuals and bilateral in 21 individuals. They further inquired 34 age-, gender, and BMI-matched control subjects. It was indicated that increasing the size of adrenal nodules is correlated with more severe hypercortisolism and less dexamethasone suppression; these cases require further investigation and possibly surgery because of increased risks of metabolic syndrome and cardiovascular mortality.