Ichikawa T, Aokage K, Miyoshi T, et al. - Researchers examined the correlation of fluorodeoxyglucose (FDG) accumulation with the expression of microenvironmental factors in radiological pure-solid lung adenocarcinoma. Fifty cases with clinical stage IA radiological pure-solid lung adenocarcinoma who were investigated with 18 F-FDG positron emission tomography (18 F-FDG PET) prior to surgery and whose FDG–PET maximal standardized uptake values (SUVmax) were calculated, were selected for inclusion. For phosphorylated AKT, glucose transporter type 1, carbonic anhydrase IX, podoplanin-positive cancer-associated fibroblasts, and CD204-positive tumor-associated macrophages, analysis of tumor specimens by immunohistochemistry was done. Outcomes revealed the existence of a close association of the SUVmax with expressions of metabolism associated markers in cancer cells as well as with tumor-promoting markers in stromal cells among patients with clinical stage IA adenocarcinoma with radiologically pure-solid nodules.