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Correlation between HDL2, HDL3 and serum ferritin levels with fatty liver and NAFLD activity score (NAS) in liver histology of organ donors

BMC Gastroenterology Nov 03, 2021

Nikeghbalian S, Rahimi R, Nikoupour H, et al. - Findings revealed a correlation of lower high-density lipoprotein (HDL2) values and HDL2/HDL3 (two types of HDL) ratio with increased nonalcoholic fatty liver disease (NAFLD) activity score among organ donors. Such an association was not found for HDL3 and ferritin.

  • This study with 100 participants was conducted to assess the link between HDL subtypes and serum ferritin levels with evidence of NAFLD in liver histology of organ donors.

  • Significantly lower serum HDL2 levels and HDL2/HDL3 ratio were detected in patients with nonalcoholic fatty liver disease activity score (NAS) > 1.

  • There was no significant correlation of serum levels of HDL3 and ferritin with NAS >1.

  • An association was found between serum ferritin > 1000 ng/ml in organ donors and raised aspartate aminotransferase and alanine transaminase levels 24 h post-transplantation in the liver organ recipient.

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