Garg D, et al. – The goals of this study are to compare levels of soluble receptor for advanced glycation end products (sRAGE), N–carboxymethyl–lysine (CML; one of the advanced glycation end products (AGEs)), and 25–hydroxy–vitamin D in the follicular fluid (FF) of women with or without polycystic ovary syndrome (PCOS), and to assess the correlation between sRAGE and 25–hydroxy–vitamin D in the FF. In women with PCOS, the low ovarian levels of the anti–inflammatory sRAGE propose that sRAGE could represent a biomarker and a potential therapeutic target for ovarian dysfunction in PCOS. Whether there is a direct causal connection amongst sRAGE and vitamin D in the ovaries remains to be determined.

Methods

• Total 25 women with PCOS who underwent IVF were prospectively selected for this study.
• Out of these 25 patients, 12 women with PCOS and 13 women without PCOS were taken part in this study.

Results

• In this study, they observed women with PCOS had majorly higher anti–Mullerian hormone levels, higher number of total retrieved and mature oocytes, and higher number of day 3 and day 5 embryos formed.
• Compared to women without PCOS, women with PCOS had significantly lower FF sRAGE levels.
• In women with PCOS, in women without PCOS, and in all participants together, there was a major positive correlation between sRAGE and 25–hydroxy–vit D.
• sRAGE positively correlated with CML in women without PCOS but not in women with PCOS.