Barnett TE, et al. - Researchers undertook this secondary data analysis of the 2017 Youth Risk Behavior Survey, to determine risk factors, including other substance use, for nonmedical prescription opioid use among US adolescents. Among 10,175 adolescents, nonmedical prescription opioid use was reported by 13.8%. The likelihood of the use of nonmedical prescription opioid was more among those aged 15 years (vs 16 years), American Indian/Alaskan Natives, and those who reported being sad or hopeless. A significant link of all other substance use with raised odds of nonmedical prescription opioid use was also observed. Among electronic vapor users, cigarette and marijuana users, and alcohol users, nonmedical prescription opioid use was 1.5 times more likely, 2 times more likely, and almost 3 times as likely, respectively. Overall, these revelations are suggestive of the requirement for more interventions for nonmedical prescription opioid use among US adolescents. Adding information on nonmedical prescription opioid use to all substance use prevention programs for adolescents is recommended.