Coronary flow reserve in patients with prior spontaneous coronary artery dissection and recurrent angina
Journal of the American Heart Association Aug 21, 2020
Sedlak T, Starovoytov A, Humphries K, et al. - Researchers investigated if there is any contribution of coronary microvascular dysfunction to post‐spontaneous coronary artery dissection (SCAD) chronic chest pain. For this purpose, they performed coronary reactivity testing at least 3 months after SCAD in 18 patients who gave consent. In the previously affected SCAD artery and 1 non‐SCAD artery, experts measured coronary flow reserve (CFR) and index of microcirculatory resistance. Findings demonstrated the presence of coronary microvascular dysfunction as suggested by abnormal CFR or index of microcirculatory resistance in at least 1 coronary artery on invasive coronary reactivity testing in >70% of patients who experienced chronic chest pain following an SCAD event. Experts also noted that coronary microvascular dysfunction was present in both SCAD and non‐SCAD arteries, this indicates that the underlying etiology may be underlying microvascular abnormalities from vasculopathies such as coronary fibromuscular dysplasia.
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