Stillman AE, Gatsonis C, Lima JAC, et al. - Researchers designed a randomized, controlled, multicenter, comparative efficacy outcomes trial (RESCUE) to assess whether initial testing with coronary computed tomographic angiography (CCTA) is non-inferior to single-photon emission computed tomography (SPECT) myocardial perfusion imaging in directing patients with stable angina to optimal medical therapy alone or optimal medical therapy with revascularization. They randomize 150 individuals from 44 sites to CCTA (n=518) or SPECT (n=532). In this study, 16.2 (SD 7.9) months was the mean follow-up time. No variation was found in outcomes of patients who had stable angina and who had undergone CCTA in comparison to SPECT as the first imaging test directing them to optimal medical therapy alone or with revascularization. The findings revealed that CCTA was a better prognosticator of MACE and revascularization.