Vergallo R, et al. - In this observational, single-center cohort study with prospective clinical follow-up, researchers examined 105 patients at the extremes of the coronary artery disease (CAD) spectrum to evaluate in vivo the coronary atherosclerotic phenotype and the prevalence and features of healed coronary plaques by optical coherence tomography (OCT) imaging. The participants were identified from OCT Registry of the Fondazione Policlinico A. Gemelli–IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Rome, Italy. A distinct atherosclerotic phenotype was exhibited by patients with recurrent acute coronary syndromes vs patients with long-standing stable angina pectoris. The former group had a higher prevalence of thin-cap fibroatheroma and lower prevalence of healed coronary plaques, which was indicative of a possible role of atherosclerotic profile and plaque healing in the natural history of patients with CAD.