Rämö JT, et al. - Researchers ascertained if people with high low-density lipoprotein cholesterol (LDL-C) or triacylglyceride levels and a family history of the same hyperlipidemia have a higher risk of coronary heart disease or distinct lipidomic profiles vs population-based hyperlipidemias, after excluding familial hypercholesterolemia. Using functional LDL receptor testing and genotyping, familial hypercholesterolemia was excluded. According to results, hyperlipidemias with family history had a similar risk of coronary artery disease vs population-based hyperlipidemias. Distinct lipidomic profiles linked to high LDL-C and triacylglycerides were identified. Lipidomic profiles were comparable between family history hyperlipidemias and population-ascertained hyperlipidemias, showing comparable and overlapping underlying mechanisms.