Coronary artery disease events and carotid intima‐media thickness in type 1 diabetes in the DCCT/EDIC cohort
Journal of the American Heart Association Dec 12, 2021
Polak JF, Backlund JYC, Budoff M, et al. - A weak association of common carotid artery intima‐media thickness (IMT), but not of internal carotid artery IMT, with subsequent coronary artery events was evident in the DCCT(Diabetes Control and Complications Trial)/EDIC (Epidemiology of Diabetes Interventions and Complications) cohort with type 1 diabetes; this link eliminated post-adjusting for coexistent conventional cardiovascular risk factors.
In this longitudinal study (EDIC), the long‐term observational follow‐up of the DCCT, a total of 1,309 participants with type 1 diabetes with a mean age of 35 years were included.
Significant links of common carotid artery IMT with subsequent coronary artery disease were found after adjustment for imaging device, gender, and age (hazard ratio [HR], 1.23 per 0.09 mm), but such links failed to remain significant following further adjustment for conventional risk factors and hemoglobin A1c (HR, 1.14 per 0.09 mm).
No significant links with subsequent coronary artery disease events were found for internal carotid artery IMT.
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