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Coronary artery disease events and carotid intima‐media thickness in type 1 diabetes in the DCCT/EDIC cohort

Journal of the American Heart Association Dec 12, 2021

Polak JF, Backlund JYC, Budoff M, et al. - A weak association of common carotid artery intima‐media thickness (IMT), but not of internal carotid artery IMT, with subsequent coronary artery events was evident in the DCCT(Diabetes Control and Complications Trial)/EDIC (Epidemiology of Diabetes Interventions and Complications) cohort with type 1 diabetes; this link eliminated post-adjusting for coexistent conventional cardiovascular risk factors.

  • In this longitudinal study (EDIC), the long‐term observational follow‐up of the DCCT, a total of 1,309 participants with type 1 diabetes with a mean age of 35 years were included.

  • Significant links of common carotid artery IMT with subsequent coronary artery disease were found after adjustment for imaging device, gender, and age (hazard ratio [HR], 1.23 per 0.09 mm), but such links failed to remain significant following further adjustment for conventional risk factors and hemoglobin A1c (HR, 1.14 per 0.09 mm).

  • No significant links with subsequent coronary artery disease events were found for internal carotid artery IMT.

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