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Coronary artery calcification is associated with mortality independent of pulmonary embolism severity: A retrospective cohort study

Clinical Radiology Oct 17, 2019

Williams MC, et al. - In 400 consecutive cases, pulmonary embolism (PE) severity was quantified via CT pulmonary angiography using the modified Miller score in order to evaluate coronary artery calcification (CAC) and vascular calcification in individuals with PE and associate this with mortality. PE severity was graded as mild, moderate, and severe in 48%, 21%, and 32% of cases, respectively. All-cause mortality transpired in 128 individuals. Individuals with CAC were three times more prone to die in comparison with those without CAC and people with severe CAC were at the greatest risk. For mortality, gender, modified Miller score, and RV/LV ratio was not predictive. In multivariate analysis, independent predictors of 3-year all-cause mortality were CAC score (CACS) and age. Of the individuals with CAC who expired, the presence of coronary artery disease was only noted in 34. Hence, in patients with PE, CACS is concluded as an independent predictor of all-cause mortality and has significant implications for following patient management.
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