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Cord Blood FABP4 levels are up-regulated at both ends of the birth weight spectrum

Acta Pediatrica May 02, 2019

Papathanasiou AE, et al. - In this investigation, researchers sought to examine the normal and abnormal intrauterine growth concentrations of fatty acid-binding protein-4 (FABP4), an adipokine associated with obesity and signs of the metabolic syndrome, at birth in term neonates and associate them with different perinatal parameters. In 80 singleton term appropriate for gestational age, intrauterine growth restricted, and large for gestational age neonates, serum cord blood FABP4 levels were prospectively determined by Elisa. A significant negative correlation was noted in the entire study population between cord blood FABP4 and gestational age. At the extremes of fetal growth at term, cord blood FABP4 levels were significantly higher and negatively correlated with gestational age, increasing early vs full-term neonates.
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