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Cord blood androgen levels of females from same sex and opposite sex twins – A pilot study

Clinical Endocrinology Aug 24, 2020

Galiano V, Solazzo G, Rabinovici J, et al. - Researchers conducted this pilot study to compare cord blood androgen levels in females from the same and opposite-sex twins. They contrasted cord blood androgens (DHEA‐S, Δ‐4 Androstenedione, total testosterone ‐ TT) and sex hormone‐binding globulin (SHBG) levels in 20 females from same-sex and 20 females from opposite-sex dichorionic diamniotic twins. The sample consisted of 20 opposite‐sex twin pairs (female‐male twins) and 20 same‐sex twin pairs (female‐female). No difference was found in the levels of androgens as Δ‐4 Androstenedione, total testosterone and SHBG among females exposed to a female co‐twin compared with females exposed to a male co‐twin. The preliminary data do not support the assumption that females exposed to male co‐twins are exposed to higher levels of androgens in utero relative to females exposed to female co‐twins.

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