Neuman RI, van der Meer MMA, Saleh L, et al. - In the present study, the researchers sought to assess the surrogates of arginine vasopressin (AVP) and atrial natriuretic peptide (ANP), C‐terminal pro‐AVP (copeptin) and mid‐regional pro‐ANP (MR‐proANP), as biomarkers for the prediction of pre‐eclampsia (PE)‐related pregnancy complications and whether they are correlated with angiogenic markers and/or clinical manifestations of PE. The sample consisted of pregnant women with suspected or confirmed PE, between December 2013 and April 2016. In total, 526 women were evaluated in the study. Women with confirmed PE showed elevated serum copeptin and MR‐proANP levels in comparison to those with suspected PE but no hypertensive disease of pregnancy. When compared with the sFlt‐1/PlGF ratio, copeptin and MR‐proANP have limited value in predicting PE‐related complications. Proteinuria, however, was associated with both copeptin and MR‐proANP, with copeptin exerting this effect independently of the sFlt‐1/PlGF ratio.