Asferg CL, et al. - A sum of 102 healthy obese males and 27 healthy men of normal weight (control group) were analyzed to study the relationship between plasma copeptin (the C-terminal portion of provasopressin as well as a stable surrogate marker for arginine vasopressin secretion) with plasma glucagon in obese vs normal weighted candidates. They noted higher (median) plasma copeptin concentrations (6.6 vs 4.9 pmol/l) and mean ± sd plasma glucagon concentrations (8.5 ± 3.8 vs 5.3 ± 1.4 pmol/l) among obese cases when compared to the normal-weight men. A positive association of copeptin with glucagon was also reported. They suggested the probability of aggravating the hyperglucagonaemic state found in obese individuals due to an increase in arginine vasopressin secretion.