Alves JM, Zink J, Chow T, et al. - Experts aspired to explore whether prenatal exposures to maternal obesity and/or gestational diabetes mellitus (GDM) and childhood lifestyle factors independently contribute to child insulin sensitivity. For this analysis, 90 children (aged 7 to 11 years) born at Kaiser-Permanente Southern California, completed an oral glucose tolerance test as part of the BrainChild Study. In order to estimate insulin sensitivity, matsuda-insulin-sensitivity-index (ISI) was used. Findings suggested no association of time spent sedentary, maternal pre-pregnancy BMI, GDM exposure, dietary added sugar, total sugar, and energy intake with ISI. Physical activity at this age was the only predictor of ISI, indicating that engaging in physical activity during childhood is beneficial for insulin sensitivity and may mitigate future metabolic disease risks.