Riccitelli GC, Disanto G, Sacco R, et al. - Researchers conducted the study for examining the contribution of sleep disturbances as measured by clinical and polysomnographic (PSG) parameters to fatigue in multiple sclerosis (MS). At baseline visit and through a home full-night PSG, demographic data and clinical features such as fatigue (as measured by modified fatigue impact scale [MFIS], neurological disability, psychiatric symptoms, medications, and sleep-related variables were collected. The study included 76 patients, with 53 (69.7%) having an MFIS ≥ 38 points. MFIS scores were positively linked to age, neurological disability, symptoms of depression and anxiety, and use of benzodiazepines and selective serotonin reuptake inhibitors. MS patients with restless leg syndrome (RLS) had significantly higher global fatigue scores than those without RLS. Future research should look into whether medical treatment for RLS can alleviate fatigue.