Ramesh D, et al. - In this study, researchers sought to examine cannabinoid type 1 (CNR1), type 2 (CNR2) receptors, fatty acid amide hydrolase (FAAH), and the vanilloid receptor (transient receptor potential cation channel subfamily V member 1 [TRPV1]) gene expression profiles among individuals with acute and chronic low back pain (cLBP) at their baseline visit. As per findings, all LBP patients had significant upregulation of CNR2 mRNA compared with controls. However, in cLBP compared with controls, FAAH mRNA and TRPV1 mRNA were significantly upregulated. They observed a significant association between FAAH SNP genotype and self-report pain measures, mechanical and cold pain sensitivity among LBP participants. Compared with acute LBP patients and controls, cLBP participants demonstrated increased FAAH and TRPV1 mRNA expression.