Falgàs N, Ruiz-Peris M, Pérez-Millan A, et al. - Experts tried to find out the associations between early-onset AD (EOAD) and frontotemporal lobar degeneration (FTLD) structural alterations and CSF biomarker levels. In this study, 138 participants (64 EOAD, 26 FTLD, and 48 controls) were enrolled, all of them with a 3T MRI brain scan and CSF biomarkers available. They applied FreeSurfer and FSL to obtain cortical thickness (CTh) and fraction anisotropy (FA) maps. They used multiple regression models to find which CSF-biomarkers better explained each disease neuroimaging signature. In this multiple regression analysis, data indicated that the biomarkers that better defined CTh values within the AD signature were Aβ and 14-3-3; whereas NfL and 14-3-3 levels explained CTh values within the FTLD signature. Likewise, NfL levels revealed FA values in the FTLD signature. In any of the models, Ng levels were not predictive. The results suggested that biochemical markers contribute differently to structural (CTh and FA) changes typical of AD and FTLD.