Wolsk E, et al. - This investigation was pursued to determine the relative contribution of cardiac and extra-cardiac disease burden and demographic factors to cardiovascular (CV) outcomes in heart failure (HF) patients with reduced (HFrEF) or preserved (HFpEF) left ventricular ejection fraction (LVEF). Based on LVEF, difference was reported with respect to the relative contribution of cardiac and extra-cardiac disease burden to CV outcomes and death in North American HF patients enrolled in the CHARM trials. Also, non-cardiac disease burden resulting in a high risk of events may help explain why cardiac disease-modifying medication proven to be efficacious in HFrEF patients has not proven beneficial in HFpEF.