Kuroda H, Abe T, Fujiwara Y, et al. - This study was carried out to evaluate hepatic perfusion using contrast-enhanced ultrasound and Doppler ultrasound in patients with acute liver failure (ALF) and investigate its utility as a prognostic biomarker. Researchers performed a prospective observational study including a total of 208 patients with acute liver injury/ALF between 2015 and 2019. They assessed 50 consecutive patients with ALF with Doppler ultrasound and contrast-enhanced ultrasound performed on admission. Furthermore, cases were classified into the following two groups: survivors (recovered without surgical intervention) and nonsurvivors (died of ALF or underwent liver transplantation). The outcomes revealed that TI (HA, LP) accurately predicts the outcome in patients with ALF and may be useful in clinical decision-making.