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Contraception and ectopic pregnancy risk: A prospective observational analysis

American Journal of Obstetrics and Gynecology Nov 09, 2020

Schultheis P, Montoya MN, Zhao Q, et al. - The rates of ectopic pregnancy in women stratified by contraceptive method used were investigated and compared with participants using no contraceptive method or condoms. Researchers conducted a secondary analysis of the Contraceptive CHOICE Project (CHOICE), a prospective cohort study of 9,256 participants that were provided the contraceptive method of their choice at no cost and followed for a duration of 2 to 3 years. Participants yielded 20,381 women-years of follow-up; 13 ectopic pregnancies were identified. At 1, 2, and 3 years, follow-up rates were 93.5%, 84.1%, and 78.9% respectively. Observations suggested a significantly lower risk of ectopic pregnancy in women using the LNG-IUD, copper IUD, DMPA, implant, and OCs, contraceptive patch, or vaginal ring relative to women using no contraception or barrier method of contraception. Relative to previous studies, this study covered a wider range of contraceptive methods and incorporated more contemporary forms of contraception.

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