Paladini G, Di Carlo S, Musella G, et al. - Researchers undertook this narrative review examining the literature concerning the safety, efficacy and current perspectives of continuous wound infiltration for postoperative pain management in different surgical settings. Of 203 identified articles, 95 were taken into consideration: 17 for the lower limb surgery; 7 for the upper limb surgery, 51 for the laparotomy/laparoscopic surgery of the abdominopelvic area, 13 studies regarding breast surgery and 7 for cardiothoracic surgery. These studies reported variable effectiveness of this technique based on the type of structure involved: it is better in structures rich in subcutaneous and connective tissue, while the effectiveness is limited in anatomic districts with greater variability of innervation. However, regardless of the heterogeneity of results, continuous wound infiltration was identified resulting in a general reduction in pain intensity and in opioid consumption: it is an outstanding analgesic technique that can be incorporated in the multimodal treatment of postoperative pain or represents a valid alternative when other options are contraindicated.