Wu W, et al. – This meta–analysis was performed to determine the relationship between hemorrhage and continuous therapy with low–dose aspirin (LDA). The physicians discovered an extremely high ratio of bleeding in the LDA–continued group compared to both the LDA–interrupted group and no–anticoagulant/antiplatelet (APT) group. However, all groups had similar ratios of en bloc resection.

Methods

• In this analysis, the authors explored data on anticoagulant/APT drugs use and continued–LDA use.
• To evaluate the quality of the included studies, the Newcastle–scale was used.
• Review Manager 5.2 was used for quality assessment statistical analysis, and the odd ratio (OR) and 95% confidence interval (CI) were calculated.

Results

•  Pooled data suggested a significantly higher bleeding ratio in the LDA–continued group compared to both the LDA–interrupted group (OR=2.05, 95% CI=1.05–3.99) and no–anticoagulant/APT group (OR=2.89, 95% CI=1.86–4.47).
•  However, the LDA–interrupted group did not differ significantly from the no–anticoagulant/APT group.
• The en bloc resection rates of the LDA–continued group versus the LDA–interrupted group, the LDA–continued group versus no–anticoagulant/APT group, and the LDA–interrupted group versus the no–anticoagulant/APT group were similar (OR=0.82, 95% CI=0.21–3.24, p=0.78; OR=0.80, 95% CI=0.24–2.65, p=0.71; OR=1.41, 95% CI=0.38–5.24, p=0.60, respectively).