Staat MA, Payne DC, Halasa N, et al. - Since 2006, active, population-based surveillance for acute gastroenteritis (AGE) hospitalizations and emergency department (ED) visits was conducted by the New Vaccine Surveillance Network in three US counties. Researchers here sought the trends in the epidemiology and disease burden of rotavirus hospitalizations and ED visits from 2006-2016. They enrolled 6,954 children with AGE and collected a stool specimen from them (2,187 hospitalized and 4,767 in the ED). Outcomes suggest that rotavirus vaccination has altered the epidemiology and disease burden of rotavirus with a biennial disease pattern. A dramatic decline in the proportion of children with rotavirus for hospitalization (49% vs 10%) and ED visits (49% vs 8%) was observed when comparison of pre- and postvaccine periods was done. In the prevaccine period, the predominant genotype observed was G1P[8] (63%); it was detected in a significantly lower proportion (7%) in the postvaccine period. G2P[4] remained stable (8% to 14%) in both periods, while there was an increase in the proportion of G3P[8] and G12P[8] from pre-to postvaccine periods (1% to 25% and 17% to 40%) respectively.