Valle JA, et al. - In this analysis of National Cardiovascular Data Registry CathPCI Registry data, researchers investigated whether management of unprotected left main (ULM) coronary artery stenosis in contemporary clinical practice accurately reflects findings reported in clinical trials. This cross-sectional multicenter analysis included ~3.3 million patients, with ~2.2 million (66.5%) male (mean age: 64.2 years). They compared ULM percutaneous coronary intervention (PCI) and all other PCI in terms of patient and procedural characteristics and their temporal trends. Of all PCI in clinical practice, <1% were represented by ULM PCI. They noted that low operator and institutional volumes, older and more comorbid patients than trial populations, and a higher frequency of adverse events characterized ULM PCI.