Batt K, et al. – The researchers evaluated the construct validity of patient–reported outcome (PRO) instruments measuring pain, functional impairment, and health–related quality of life in US people with hemophilia (PWH) with a history of joint pain/bleeding. In describing effects of hemophilia, all PRO instruments had high construct validity but provided different levels of detail. Instrument choice could depend on individuals’ symptoms, treatment planning goals, or outcome tracking research objectives, with consideration for the administrative burden.