Abdulrahim H, Jiao Q, Swain S, et al. - This study was undertaken to investigate the risk of association with hip osteoarthritis (OA) of 14 morphological features measured on standard anteroposterior pelvis radiographs. The Genetics of OA and Lifestyle database was applied to perform a case-control study of 566 symptomatic unilateral hip OA cases and 1,108 controls without hip OA. Clusters of morphological features were distinguished by using Hierarchical clustering on the principal component method. Receiver operating characteristic analysis was applied to calculate the proportional risk contribution of these morphological features in the context of other risk factors of hip OA. The data exhibited that constitutional morphological variation strongly associates with hip OA development and may explain much of its heritability. It has been reported that the relevant morphological measures can be assessed readily on standard radiographs to help predict the risk of hip OA. Prospective trials are needed to provide further support for causality.