Nedopekina E, Escura S, Cobo T, et al. - Researchers investigated likely predictive factors to predict the failure of conservative treatment of non-tubal ectopic pregnancy, in this retrospective single-center study. They evaluated the rate of failure, complications as well as the requirement for additional interventions of the different primary treatment regimens in non-tubal ectopic pregnancies that happened in their center in Spain. The conservative treatment regimens employed were: medical (systemic single or multiple dose methotrexate; ultrasound-guided intrasaccular injection of methotrexate or chloride potassium; surgical (oophorectomy in case of ovarian ectopic pregnancy, surgical curettage). This analysis involved 39 cases. Success of primary treatment was noted in 74% (29/39). A significantly increased probability of failure of the primary treatment was noted in relation to presence of embryo heartbeat. The risk of treatment failure rose by 54% in relation to every doubling of the β-hCG (human chorionic gonadotropin) levels. Findings demonstrated the safety of conservative treatment for non-tubal ectopic pregnancy. The suggested predictive factors of failure of conservative treatment were: presence of embryo heartbeat and β-hCG levels at diagnosis.