Ladomenou F, et al. - In this analysis, researchers investigated the effect of vaccination on bacterial meningitis over a period of 27 years in a well-defined children's population on the island of Crete, Greece. This was a retrospective observational study of all compulsory bacterial meningitis notifications from 1991-2017 in patients aged one month to 14 years. Findings revealed that there were 245 patients with proven (n = 227) or suspected (n = 18) bacterial meningitis and eight deaths, resulting in a case fatality rate of 3.3%. Data reported that the mean annual incidence rate per 100,000 children was 4.9 for Neisseria meningitidis, 2.2 for Streptococcus pneumoniae and 0.4 for Haemophilus influenzae type b (Hib). Investigators found that cases of bacterial meningitis reduced in children following the introduction of the Meningitis C and PCV13 vaccines in Greece. Hib had already vanished and major reeductions were observed in meningitis C and Streptococcus pneumoniae.