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Conization pathologic features as a predictor of intermediate and high risk features on radical hysterectomy specimens in early stage cervical cancer

Gynecologic Oncology Feb 08, 2019

Hutchcraft ML, et al. - Among patients with early stage cervical cancer, researchers assessed the additive value of pathologic features of a cone biopsy toward identifying patients with high risk tumors for which adjuvant therapy may be indicated. Using a restrospective approach, 115 patients with early stage cervical cancer undergoing a conization followed by radical hysterectomy from 1995 to 2016 were identified and their clinical and pathologic data were analyzed (70.5% were low risk, 10.4% intermediate risk, and 19.1% were high risk on pathology assessment). Risk stratification was not significantly influenced by the additive pathology of the conization and hysterectomy specimen in women with early stage cervical cancer; the influence was seen only on 4.3% of patients. However, in 60% and 37% of cases, the presence of lymphovascular space invasion (LVSI) in the conization was found to be related to intermediate risk criteria and high risk criteria, respectively. The selection of primary treatment for women with cervical cancer could be impacted by the assessment of LVSI in conization specimens as patients with intermediate/high risk criteria would meet recommendations for adjuvant therapy.
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