Kheir F, Thakore SR, Uribe Becerra JP, et al. - Researchers undertook this retrospective analysis to evaluate the diagnostic yield of electromagnetic navigation bronchoscopy (ENB) plus cone-beam computed tomography (CBCT) vs ENB alone for biopsy of peripheral lung nodules. They obtained data from 62 consecutive patients having lung nodules located in the outer two-thirds of the lung who received ENB and combined ENB-CBCT. In univariate analysis, ENB-CBCT and ENB had a diagnostic yield of 74.2% and 51.6%, respectively. After multivariate regression analysis adjusting for the size of the lesion, distance from the pleura, and presence of bronchus sign, the estimated odds ratio for the diagnostic yield was 3.4 (95% CI 1.03–11.26) in the ENB-CBCT group vs ENB alone. Overall, experts concluded that an increased diagnostic yield might be conferred by CBCT when used in combination with ENB for biopsy of peripheral lung nodules.