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Conditional survival after neodjuvant chemotherapy and surgery for oesophageal cancer

British Journal of Surgery Feb 11, 2020

Hagens ERC, Feenstra ML, Eshuis WJ, et al. - Researchers investigated patients with oesophageal cancer for conditional survival and created a nomogram predicting the conditional probability of survival after oesophagectomy. In this retrospective study, they included 660 patients with oesophageal cancer who received neoadjuvant chemoradiation followed by oesophagectomy between January 2004 and 2019. Median overall survival was 44·4 months. Following surgery, a direct increase in the probability of achieving 5-year overall survival after resection was noted with each additional year survived; it directly increased from 45% to 54%, 65%, 79% and 88% given 1, 2, 3 and 4 years already survived respectively. Independent predictors of survival were cardiac co-morbidity, cN category, ypT category, ypN category, chyle leakage and pulmonary complications. Using these predictors and number of years already survived, the nomogram predicted 5-year survival.
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