Gebhardt BJ, et al. - In this retrospective analysis, researchers examined patients treated with adjuvant radiation therapy (RT) with or without concurrent chemotherapy to determine the effect of prognostic and treatment factors by analyzing data of 128 patients treated with surgical resection followed by intensity-modulated radiotherapy. The study results showed that the use of chemoradiotherapy for adjuvant treatment of salivary gland malignancies was well-tolerated. However, no improvement in survival was seen with the use of chemoradiotherapy in both the overall study population and a subset with high-risk features. Age, tumor stage, nodal stage, positive surgical margins, histology, high grade, perineural invasion, lymphovascular space invasion, extranodal extension, and use of chemoradiotherapy were predictors of decreased progression-free survival (PFS) on univariate analyses. Elevated T-stage, positive surgical margins, and presence of extranodal extension were predictive of decreased PFS on multivariable analysis.