Mofors J, et al. - In this investigation, researchers evaluated the risk of incident cardiovascular disease in patients with primary Sjögren's syndrome, overall and stratified by Ro/SSA and La/SSB autoantibody status. In Sweden, a cohort of 960 patients with primary Sjögren's syndrome and 9,035 matched controls from the general population were involved, and data from the National Patient Register were extracted to identify events of myocardial infarction, cerebral infarction, and venous thromboembolism. Using cox proportional hazard regressions, hazard ratios (HRs) were estimated. Data reported that the overall HR was 1.6 for myocardial infarction, 1.2 for cerebral infarction, and 2.1 for venous thromboembolism during a median follow-up of 9.5 years. According to findings, primary Sjögren's syndrome is linked to a markedly raised risk of cardiovascular disease and the presence of Ro/SSA and La/SSB autoantibodies identify the subgroup of patients carrying the highest risk. These outcomes suggest that cardiovascular disease monitoring and prevention should be considered in this patient group.