Tempfer CB, et al. - Given that pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new means of delivering chemotherapy into the abdomen of patients with peritoneal carcinomatosis (PC), researchers assessed the amount of drug uptake in ascites and peritoneum after PIPAC. Findings suggested a significant chemotherapy uptake in both ascites and peritoneum in association with PIPAC, suggesting a bimodal cytotoxic effect of PIPAC via direct tissue uptake into peritoneal tumor nodules and via ascites. Consecutive PIPAC applications result in peritoneal accumulation of doxorubicin, indicating a cumulative cytotoxic effect of doxorubicin after repeated PIPACs.