Francis-Morris A, et al. - Given the correlation of persistent CD4:CD8 ratio inversion (< 1) with mortality in older people, researchers examined how the effects of baseline CD8 count and age at HIV diagnosis influence CD4:CD8 ratio recovery with antiretroviral therapy (ART). Using routinely collected data from the HIV outpatient services at Imperial College Healthcare NHS Trust, London, UK, they conducted an observational study from January 1, 2007, to 31 December 31, 2016. They included data of 876 patients starting ART, where HIV suppression was achieved; of these patients, 741 (84.6%) were male and 507 (57.9%) were Caucasian. The median time on ART of 38 [IQR 17–66] months was reported. Findings revealed an association of older age (> 50 years) at HIV diagnosis with persistent CD4:CD8 ratio inversion, whereas treatment of primary HIV infection was identified as protective. Findings thereby affirm the necessity for testing and early treatment of people aged > 50 years, and could be employed in a risk management algorithm for intensified surveillance.